General

What is amniotic test?

What is amniotic test?

Dr. Vehbi Koç Foundation American Hospital Women's Health Unit. Cem Ayhan, It is vital for the baby to continue normal development while in the womb, and provides information about the Amniotic Synthesis Test which provides early diagnosis in genetic and important diseases and draws attention to its necessity.

- What's amniotic fluid?

Every baby needs a liquid called n Amniotic Mayi için to grow up in the womb. This fluid protects the baby against external influences such as heat changes, infection, shock, and is vital for the baby to maintain normal development.

The content of amniotic fluid is very similar to the mother's serum; In addition, it is a liquid containing baby cells. The baby drinks this liquid and urinates into it. Many substances, such as urea, bilirubin, and alfafetoprotein, come from the baby's body. The content of this liquid is not stable and is filtered by the mother 10-12 times a day. The amount of amniotic fluid increases as the gestational week progresses and reaches approximately 800 ml in a 9-month pregnancy.

- What is amniocentesis?

- When is amniocentesis performed?

During pregnancy, amniocentesis can be performed at different times to investigate genetic diseases and to treat some diseases. The test, which is widely known in the society and carried out to investigate the genetic structure of the baby, is called Genetic Amniocentesis Test. This test is performed in the first half of pregnancy. At this stage, the chromosome structure of the baby can be determined with an accuracy of 100% by amniocentesis. In the same period, some hereditary genetic diseases can be diagnosed.

- In what cases?

The maternal age is more than 35 years, those who previously had a baby with chromosomal anomaly; 3 or more pregnancies with spontaneous abortion; those with known chromosomal / genetic disease of the mother or father; family history of chromosomal anomaly; mothers with transient diseases linked to the X chromosome to which they are carriers; those at risk for metabolic disease; those at risk for neural tube defects; screening tests (presence of increased risk in double or triple screening tests) should be tested by Amniocentesis for the diagnosis of genetic diseases.

- What diseases are diagnosed by amniocentesis?

Today, the diagnosis of many metabolic diseases can be established by amniocentesis. However, screening of metabolic diseases cannot be performed in all centers. Genetic Amniocentesis is usually performed at 15 to 17 weeks of gestation. However, in some cases, it can be done in the early period between the 12th and 14th weeks of pregnancy.

How is amniocentesis performed?

This procedure is painless. It does not require any anesthesia. Amniocentesis was performed in a manner similar to the ultrasound examinations and firstly an obstetric ultrasonography was performed to determine the position of the baby in the womb; whether there is a concomitant anomaly; the size of the baby; Placenta location is checked and recorded.

Once the appropriate site is determined, the amniocentesis site is prepared by cleaning with antiseptic solutions. In this region, approximately 20 ml of liquid is aspirated into the amniotic sac under ultrasound examination with an extremely fine needle and delivered immediately to the laboratory for genetic examination.

- What should be considered after amniocentesis?

As with any surgical intervention, resting for an appropriate period of time is necessary to protect oneself and the baby from possible side effects. Physical activity should be reduced as much as possible within the first 24 hours following amniocentesis, and bed rest should be performed if possible. Sexual contact should not be made for 3 days after amniocentesis. After amniocentesis, high fever, severe abdominal pain, persistent cramps, bleeding in vagina or fluid discharge should be urgently applied to a health institution.

- When do the results come up?

It takes approximately 1-3 weeks to determine the genetic structure of the baby by amniocentesis and this process may vary according to the growth rate and quantity of the baby cells produced in the laboratory. Some laboratories may provide preliminary results of some common genetic diseases over a period of 24 to 48 hours using a method called FISH. If certain diseases are to be sought, the time required to diagnose them varies.

Is Amniocentesis Safe? What are the complications?

Amniocentesis performed at 15 weeks of gestation or later carries a risk of ending with 0.5% miscarriage in 200 cases. This risk is equal to a 35-year-old woman's risk of having a baby with Down's Syndrome. If amniocentesis is performed before the 15th week of gestation, the risk of miscarriage increases to about 1%. Therefore, amniocentesis should be performed by specialists and experienced physicians in well-equipped health centers and the results should be evaluated in experienced genetic laboratories.